(Phys.org) —Look what might help us live longer—worms! Researchers at the Boyce Thompson Institute for Plant Research (BTI) and Cornell have shown that roundworms can live up to 20 percent longer when bathed in their own secretions.
The family of chemicals involved—ascarosides—also make these slippery, tiny worms more resistant to different types of stress.
Understanding this chemical model, which was published online in the Proceedings of the National Academy of Sciences March 18—might help humans live longer, say the researchers.
"It seems that the ascarosides trigger stress-resistance mechanisms that ultimately slow aging, a process that could lead to a better understanding of human aging and how it may be delayed," says senior author Frank Schroeder, assistant professor at BTI on the Cornell campus and in Cornell's Department of Chemistry and Chemical Biology. The first authors are postdoctoral scientist Andreas Ludewig and doctoral student Yevgeniy Izrayelit.
The anti-aging effects of ascarosides depend on signaling pathways that are evolutionarily conserved. In other words, the researchers think that similar mechanisms of lifespan regulation may be at work in animals and humans, too. Ascaroside-promoted longevity appears to require a protein called sirtuin—a factor already known to be important for the biology of human aging and stress.
For humans, the chemical resveratrol found in red grapes and red wine has been suggested to increase lifespan through activation of the sirtuins. The worm-made ascarosides seem to increase lifespan by a similar mechanism, but they are roughly 1,000-times more effective than the grape-derived resveratrol.
Why use these worms, a type of nematode, to model human biology? Schroeder explains that human research on aging could take hundreds of years, while generation-cycles for nematodes—in this case C. elegans—takes but a few weeks. Discoveries from nematode research have already yielded important insight in several human diseases, most importantly diabetes, and Schroeder's work further emphasizes the relevance of nematodes for understanding longevity.
The study, "Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1," was funded by the National Institutes of Health.
Explore further: Worm sugarcoats bacterial toxins to stave off death
More information: www.pnas.org/content/early/2013/03/13/1214467110
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Display comments: newest first1 / 5 (1) Mar 29, 2013 Perhaps this explains why drinking one's own urine is so popular in America.On the Christian News Service, this research is being touted as another example of how Good Christian Patriots are having their money stolen by the Evil American Government and wasted on this study of worm Excrement.
The study of worm excrement is scientific excrement they say.
Apparently "Obummer" is personally directing the funds to all manner of scientific waste and fraud in order to destroy the American people and foster the takeover of the world by "Muslin" extremists.
1 / 5 (1) Mar 29, 2013 This has been known for ages. Even when I was an undergrad doing my dissertation and research on C.elegans I came across its genes that allow "dauer" formation, and slowed metabolisms etc. This is barely new discovered here. (Phys.org) —While the natural world is replete with compounds that form the basis of many disease-fighting pharmaceuticals, it is also the case that humans and other mammals produce their own host-defense ...
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